What is Ibrance 125mg (Palbociclib) ?
Ibrance 125mg (Palbociclib) is used in men and women to treat certain types of advanced breast cancer that has spread to other parts of the body.
Ibrance 125mg (Palbociclib) works by recognizing certain types of cancer cells and blocking the action of chemicals that cause them to divide and grow. This may slow down or stop cancers from growing and dividing.
Each opaque, hard gelatin size 2 capsule with light orange cap and body, printed with white ink “Pfizer” on the cap, “PBC 75” on the body, contains 75 mg of palbociclib. Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, and magnesium stearate; capsule shell: gelatin, red iron oxide, yellow iron oxide, and titanium dioxide; printing ink: shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone.
Each opaque, hard gelatin size 1 capsule with caramel cap and light orange body, printed with white ink “Pfizer” on the cap, “PBC 100” on the body, contains 100 mg of palbociclib. Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, and magnesium stearate; capsule shell: gelatin, red iron oxide, yellow iron oxide, and titanium dioxide; printing ink: shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone.
Each opaque, hard gelatin size 0 capsule with caramel cap and body, printed with white ink “Pfizer” on the cap, “PBC 125” on the body, contains 125 mg of palbociclib. Nonmedicinal ingredients: microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and hard gelatin capsule shells; capsule shell: gelatin, red iron oxide, yellow iron oxide, and titanium dioxide; printing ink: shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone.
How to use?
The recommended dose of palbociclib is 125 mg taken by mouth, once a day for 21 days, followed by 7 days without taking the medication. This forms a 28-day cycle, which is repeated as long as you are benefiting from the medication.
Take palbociclib with food. Try to take this medication at the same time each day, to make sure a constant amount of medication stays in your body.
Swallow the capsule whole with some fluid. Do not crush, chew, or open the capsule before swallowing it. If you find a broken, cracked, or open capsule, discard it safely. Do not take any capsule that is not intact.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage.
Serious side effects include:
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
low white blood cell counts–fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
low red blood cells (anemia)–pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
signs of a blood clot in the lung–chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
nausea, vomiting, diarrhea, loss of appetite;
mouth sores, decreased sense of taste;
weakness, feeling tired;
numbness, tingling, or burning pain in your arms, legs, hands or feet;
abnormal liver function tests;
cold symptoms such as stuffy nose, sneezing, sore throat;
dry skin, temporary hair loss.
This is not a complete list of side effects and others may occur.
Which drugs or supplements interact with Ibrance (Palbociclib) ?
There may be an interaction between palbociclib and any of the following:
alpha blockers (e.g., alfuzosin, doxazosin, silodosin, tamsulosin)
anti-cancer medications (e.g., cabazitaxel, docetaxel; doxorubicin; etoposide, ifosfamide, irinotecan, vincristine)
anti-psychotics (e.g., aripiprazole, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
“azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
benzodiazepines (e.g., chlordiazepoxide, clonazepam, diazepam, lorazepam)
calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
corticosteroids (e.g., budesonide, dexamethasone)
estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
“gliptin” diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
macrolide antibiotics (e.g., clarithromycin, erythromycin)
narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
St. John’s wort
seizure medications (e.g., carbamazepine, gabapentin, levetiracetam, phenytoin, topiramate)
selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
“statin” anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)